When will tumor gene expression profiling be incorporated into clinical breast cancer decision making?
نویسندگان
چکیده
منابع مشابه
Gene expression profiling of circulating tumor cells in breast cancer.
BACKGROUND Determining the transcriptional profile of circulating tumor cells (CTCs) may allow the acquisition of clinically relevant information while overcoming tumor heterogeneity-related biases associated with use of tissue samples for biomarker assessment. However, such molecular characterization is challenging because CTCs are rare and outnumbered by blood cells. METHODS Here, we descri...
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Differences in the expression of specific genes within breast tumors have been associated with risk of recurrence after treatment. Most women with Stage I or II node-negative breast cancer (especially when estrogen-receptor positive and treated with tamoxifen) remain disease-free at 10 years. Information on risk of recurrence could help identify women most likely to benefit from chemotherapy. S...
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Chemotherapy and hormonal therapy as adjuvant systemic therapies to inhibit breast cancer recurrence are not necessary for each patient. In Veer‟s paper “Gene expression profiling predicts clinical outcome of breast cancer” (Nature 2002, PMID: 11823860), they introduced a method based on DNA microarray technology, which tried to identify a gene expression profile with high cancer recurrence pot...
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Gene expression assays that are used in daily clinical practice for treating early breast cancer patients have been introduced in the clinic only recently. This review discusses the development of these arrays, summarizes the validation of those that are commercially available and indicates how the information provided by these assays can help in the care of patients. The review also provides a...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2006
ISSN: 1465-542X
DOI: 10.1186/bcr1519